Realmente en esta pandemia, aun desconocemos muchos datos relevantes que en el futuro próximo se darán a conocer sin duda alguna. Creería que lo primero, que desconocemos es el aporte del Dr. Li Wenliang, quien, en el hospital de Wuhan, detectó 7 pacientes con Neumonía que se asemejaba al SARS del 2003, y alertó a sus colegas del inminente peligro de contagio; los enfermos provenían todos del mercado de pescados y mariscos de Huanan, ya a finales de diciembre Li, publico en la red social China Weibo, un documento médico en el que detallaba el nuevo Coronavirus. Allí empezó su calvario, fue acusado oficialmente de difundir falsos rumores, torturado y finalmente murió por neumonía el 7 de febrero. Su muerte causò una ola de ira y dolor en las redes sociales de China. El 20 de enero del 2020, China declara la emergencia por el brote de SARS Cov-2 y es hasta el 30 de enero que la OMS declara la emergencia de salud pública por el nuevo SARS Cov-2, pero ya para esa época 5 millones de chinos habían viajado por todo el mundo. El 6 de febrero del 2020, aparecen las dos primeras personas fallecidas por C-19, en Estados Unidos y empiezan las Olas en el mundo, como brotes por países causando hasta la fecha 22 millones de muertes, millones de contagiados (425 millones), millones de vacunados (5 mil millones), 50 mil millones de dólares invertidos en vacunas y hoy, llegamos a Omicrón y sus 3 linajes, de las cuales BA.2 las más contagiosa, la más indetectable y más lesiva, predomina en la actualidad y esta próxima a desaparecer como todas las anteriores. Todos los datos son aportados por la Universidad de Johns Hopkins (JH) para la OMS y el CDC de Atlanta.
Interesantemente, al inicio de la Pandemia, JH, reportaba el numero de contagiados, muertos y recuperados y luego dejo de reportar los recuperados, posteriormente dejó de reportar los muertos y hoy en día ya no hace ningún reporte, coincidiendo con el final social y político de la Pandemia. Sí, así es, socialmente la Pandemia ha finalizado, pero biológicamente quedan aproximadamente 12 meses mas de pandemia. Cuántas Olas de variantes preocupante van? veamos esto con detalle: 1 Alpha, 2 Beta, 3 Gamma, 4 Delta, 5 Omicrón. Y vendrán 3 o 4 mas variantes preocupantes próximamente. Pero aquí está el punto que, nos reúne en esta nota de revisión. Antes de Delta, aparece en el mundo una nueva Ola que ha sido desconocida por todos social y políticamente, no tiene letra del alfabeto griego y se conoce en el mundo medico como Covid Crónico, ósea es la 4 ola, oculta e ignorada por todos, menos por 18 millones de habitantes que padecen de esta enfermedad, que ya han sido diagnosticados y ahora imagínense la cantidad de personas con síntomas de Covid Crónico, que deambulan por sistemas de atención de salud, que aun no conocen ni los síntomas ni a los enfermos, por lo tanto Delta es la 5ª ola y Omicrón es la 6ª Ola.
Pasaremos a describir, lo que es hoy en día una sub-peste en la salud publica por sus múltiples secuelas por más de un año en los enfermos. Al principio, en marzo del 2021, sale la primera revisión muy completa de Covid Crónico publicada en Nature Medicine, para hoy ya hay mas de 6 revisiones muy completas, la diferencia con la primera es que ya existe una propuesta de manejo medico farmacológico que al principio solo era la descripción de la enfermedad.

En esta revisión, describiéremos la 4ª Ola, que aún desconocen millones personas y enfermos, en el mundo. Necesitamos socializarla y que estas personas busquen ya ayuda por grupos profesionales tras disciplinares para obtener asistencia médica y de neuro rehabilitacion. La Dra Ani Nalbandian, cardióloga de la Universidad de Columbia, en la ciudad de New York, es la autora principal de este grupo de médicos que hacen tan excelente descripción titulada: Síndrome de Covid-19 Postagudo, conocido hoy en día como Covid Crónico. Al principio los sobrevivientes de enfermos de C-19, mientras eran egresados a sus domicilios, una fila de médicos y enfermeras los aplaudían por que iban vivos, pero no sabían que salían muy enfermos, por lo menos esta practica ya fue abandonada. Fueron los grupos de defensa de los pacientes, quienes alertaron, para que el sistema de salud identificara y contribuyera al reconocimiento de este síndrome, ya que a los enfermos de Covid Crónico, no les creían que seguían mas enfermos, con PCR negativa. Ya existen, publicaciones de pacientes con Covid crónico, con más de un año con síntomas muy relevantes de esta patología oculta para muchos profesionales de la salud. Esta enfermedad se caracteriza principalmente por la presencia de síntomas persistentes y/o complicaciones retardadas o a largo plazo, de los mismos síntomas de 7 órganos afectados. Los principales síntomas son fatiga, ahogo, dolor en el pecho, trastornos neurocognitivos (alteraciones de la memoria, atención y funciones ejecutivas del cerebro), artralgias, caída del cabello y lesiones al sistema neuro-emocionales y neuro-musculares. El grupo de investigadores realizó un estudio observacional de 38 hospitales de Michigan. Evaluaron a 1.250 pacientes dados de alta vivos, a los 60 días del egreso hospitalario, utilizando los registros sanitarios y encuestas telefónicas. Durante el periodo del estudio, murió el 6.7% de los egresados, el 15.1% requirió ser re-ingresado nuevamente por empeoramiento de los síntomas crónicos. El 32.6% de los pacientes reportó síntomas persistentes, el 18.9% reportó síntomas nuevos o empeoramiento de su estado clínico. El 22.9% reportó ahogo al subir las escaleras de sus domicilios, y el 15.4% reportó persistencia de la perdida del gusto y el olfato. Con base en los datos clínicos y a la línea del tiempo como la prueba de PCR, ya negativa, se clasificó esta enfermedad en: 1. Covid-19 sintomático o subagudo en curso, que incluye síntomas presentes de 4-12 semanas después de la infección aguda post Covid, y 2. Síndrome Crónico post Covid-19, que incluyen síntomas mas allá del 3 mes del egreso. Mientras esto sucedía en USA, Francia, Italia, España y China también iniciaban reportes muy parecidos en la frecuencia de los mismos síntomas. Una pregunta interesante, es por qué sucede esto? el virus produce toxicidad directa a los tejidos afectados, daño endotelial sistémico, lesión inmunitaria, estimulación permanente de un sistema proinflamatorio persistente e hipercoagulabilidad continua. El tiempo y ya la asistencia sanitaria nos dirá, como será la vida en 5 años de estos sobrevivientes con persistencia crónica de síntomas post-Covid-19.



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